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A common misconception is CBD from hemp is not as good as CBD from cannabis, or CBD needs a small amount of THC to be "active" or effective. While the ‘Entourage Effect’ tells us cannabinoids and terpenes can work together to provide certain benefits, this doesn’t mean cannabinoids have no value on their own. Each cannabinoid does have its own set of benefits. The best way to explain the benefits of CBD, or cannabidiol, is to explain exactly how the cannabinoid works within the body.

A Multi-Use Cannabinoid

CBD interacts with the body in many ways. Ironically, it has little affinity for the endocannabinoid receptors themselves, and works by binding and stimulating other receptors in the body.

  • Serotonin Receptors – Research has indicated CBD directly stimulates the serotonin receptors which are involved in several biological processes, including anxiety, addiction, appetite, sleep, pain perception, nausea and vomiting.
  • Vanilloid Receptors – By binding to TRPV1, CBD can help mediate pain perception, inflammation and body temperature. Named for the effects of the vanilla bean, which contains eugenol, an essential oil that has antiseptic and analgesic properties; it also helps to unclog blood vessels.
  • “Orphan” Receptors (GPR55) – Acting as an antagonist, CBD can block or deactivate this receptor, which is a good thing, because when active this receptor is thought play a part in osteoporosis, various types of cancer, and bone reabsorption.
  • “Nuclear” Receptors (PPARS) – Activating these receptors has shown an anti-proliferative effect in some studies. In addition, PPAR activation may even be linked to reducing the chances of developing Alzheimer’s disease. These receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions.

Beyond Receptors

The benefits of cannabidiol don’t stop with the receptors it binds with; CBD exerts other functions within the body as well.

  • Reuptake Inhibitor – CBD, like many other substances, binds with fatty acids to enter the bloodstream. However, CBD is a competitive inhibitor, meaning it’s so excited to hook up with the fatty acids it competes with other substances to bind first. In doing so, CBD slows down the reabsorption of naturally produced endocannabinoids, like anandamide. CBD also slows the reuptake of adenosine which can produce anti-anxiety and anti-inflammatory effects.
  • Allosteric Modulator – CBD can alter the shape of certain receptors to enhance or inhibit how they perform. For example, CBD can reduce anxiety by changing the GABA-A receptor to increase the natural calming effect of GABA. CBD also alters the CB1 receptor in this way, which is how it mitigates the cerebral effect of THC.

Understanding how CBD interacts with the receptors in your body clearly shows CBD, or cannabidiol, has benefits for health and wellness in multiple ways. Although other cannabinoids may provide additional benefits to the one’s listed here, CBD can provide a number of benefits as an isolated extract. Whether produced from hemp or cannabis, the CBD molecule itself is exactly the same. Get your quality, hemp extracted, cannabidiol today at Sunshine Hemp Co.


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